Symposium C-12: Mechanical Behaviors of Cytoskeleton and Cells

(Mechanics of Biological and Soft Materials)

Symposium Organizers:

Taeyoon Kim, Purdue University
kimty@purdue.edu

Zhangli Peng, University of Notre Dame
zpeng3@nd.edu

Symposium Technical Description

Cells are intrinsically mechanical, which need to produce and sense mechanical forces for their biological processes, such as migration, cytokinesis, and embryonic development. The generation and sensing of the forces are deeply involved with actin cytoskeleton consisting of actin filament, cross-linker, molecular motor, and actin-associated proteins. During recent decades, the mechanical behaviors of cells and actomyosin contractility have been vigorously studied via theories, simulations, and in vitro and in vivo experiments. This symposium will cover state-of-the-art studies involved with the following topics:

  • Single and collective cell migration
  • Cytokinesis
  • Cellular mechano-sensing
  • Morphogenesis
  • Rheological measurements of cells
  • Actomyosin contractility

Technical Program

Tuesday | T1 10:00am-11:40am

C12-1: Mechanical Behaviors of Cytoskeleton and Cells
Room 2111 Session Chair: Taeyoon Kim, Zhangli Peng Track C: Mechanics of Biological and Soft Materials
10:00 am A chemo-mechanical model for cell-mediated fiber recruitment, focal adhesion growth and extracellular matrix mechanosensing in fibrillar microenvironments (Invited)

Vivek Shenoy

10:40 am Strain-enhanced stress relaxation of collagen gels and implications for matrix remodeling by cells (Invited)

Sungmin Nam, Ovijit Chaudhuri

11:00 am Mechanosensing in filopodia dynamics and structural mechanics of viscoelastic ECM fiber networks (Invited)

Min-Cheol Kim, Hyeonyu Kim, Rohan Abeyaratne, Roger D. Kamm, H. Harry Asada

11:20 am A thermodynamical model of cell-substrate interactions (Invited)

Tiankai Zhao, Sulin Zhang

 

Tuesday | T2 13:00pm-14:40pm

C12-2: Mechanical Behaviors of Cytoskeleton and Cells
Room 2111 Session Chair: Taeyoon Kim, Zhangli Peng Track C: Mechanics of Biological and Soft Materials
13:00 pm Cell sensing and motility in confinement (Invited)

Konstantinos Konstantopoulos

13:40 pm Using cytoskeletal waves for texture sensing and directed cell migration (Invited)

Sebastian Schmidt, Wolfgang Losert

14:00 pm Microtubules’ role in positioning the centrosome during 1D cell migration (Invited)

Katrina Adlerz, Helim Aranda-Espinoza

14:20 pm Computational study of cell migration behaviors

Xiaowei Zeng, Liqiang Lin

Tuesday | T3 15:00pm-16:40pm

C12-3: Mechanical Behaviors of Cytoskeleton and Cells
Room 2111 Session Chair: Taeyoon Kim, Zhangli Peng Track C: Mechanics of Biological and Soft Materials
15:00 pm Stress fiber contractile behaviors in aortic valve interstitial cells (Invited)

Michael Sacks, Yusuke Sakamoto, Rachel M. Buchanan, Johannah S. Adams, Farshid Guilak

15:40 pm Electrohydrodynamic instability of a lipid bilayer membrane coupled to a cytoskeleton network (Invited)

Yuan-Nan Young

16:00 pm Water dynamics and actomyosin mechanics govern cell mechanical behavior (Invited)

Sean Sun

16:20 pm Mechanics of red blood cells in human spleen and some consequences for health and disease

Zhangli Peng, Igor Pivkin, George Karniadakis, Pierre Buffet, Ming Dao

 

Wednesday | W1 10:00am-11:40am

C12-4: Mechanical Behaviors of Cytoskeleton and Cells
Room 2111 Session Chair: Taeyoon Kim, Zhangli Peng Track C: Mechanics of Biological and Soft Materials
10:00 am How actin polymerization generates pulling forces to bend the cell membrane (Invited)

Anders Einar Carlsson, Dennis Tweten, Philip Bayly

10:40 am Mechanochemical modeling of the eukaryotic cytoskeleton (Invited)

Garegin A. Papoian

11:00 am 3D model of cytokinetic contractile ring assembly: node-mediated and “backup” pathways (Invited)

Dimitrios Vavylonis, Tamara Bidone

11:20 am Morphological transformation, contraction, and force generation of active cytoskeletal structures

Taeyoon Kim, Wonyeong Jung, Jing Li