(Mechanics of Biological and Soft Materials)
Symposium Organizers:
Taeyoon Kim, Purdue University
kimty@purdue.edu
Zhangli Peng, University of Notre Dame
zpeng3@nd.edu
Symposium Technical Description
Cells are intrinsically mechanical, which need to produce and sense mechanical forces for their biological processes, such as migration, cytokinesis, and embryonic development. The generation and sensing of the forces are deeply involved with actin cytoskeleton consisting of actin filament, cross-linker, molecular motor, and actin-associated proteins. During recent decades, the mechanical behaviors of cells and actomyosin contractility have been vigorously studied via theories, simulations, and in vitro and in vivo experiments. This symposium will cover state-of-the-art studies involved with the following topics:
- Single and collective cell migration
- Cytokinesis
- Cellular mechano-sensing
- Morphogenesis
- Rheological measurements of cells
- Actomyosin contractility
Technical Program
Tuesday | T1 10:00am-11:40am
| C12-1: Mechanical Behaviors of Cytoskeleton and Cells | ||
| Room 2111 | Session Chair: Taeyoon Kim, Zhangli Peng | Track C: Mechanics of Biological and Soft Materials |
| 10:00 am | A chemo-mechanical model for cell-mediated fiber recruitment, focal adhesion growth and extracellular matrix mechanosensing in fibrillar microenvironments (Invited)
Vivek Shenoy |
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| 10:40 am | Strain-enhanced stress relaxation of collagen gels and implications for matrix remodeling by cells (Invited)
Sungmin Nam, Ovijit Chaudhuri |
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| 11:00 am | Mechanosensing in filopodia dynamics and structural mechanics of viscoelastic ECM fiber networks (Invited)
Min-Cheol Kim, Hyeonyu Kim, Rohan Abeyaratne, Roger D. Kamm, H. Harry Asada |
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| 11:20 am | A thermodynamical model of cell-substrate interactions (Invited)
Tiankai Zhao, Sulin Zhang |
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Tuesday | T2 13:00pm-14:40pm
| C12-2: Mechanical Behaviors of Cytoskeleton and Cells | ||
| Room 2111 | Session Chair: Taeyoon Kim, Zhangli Peng | Track C: Mechanics of Biological and Soft Materials |
| 13:00 pm | Cell sensing and motility in confinement (Invited)
Konstantinos Konstantopoulos |
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| 13:40 pm | Using cytoskeletal waves for texture sensing and directed cell migration (Invited)
Sebastian Schmidt, Wolfgang Losert |
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| 14:00 pm | Microtubules’ role in positioning the centrosome during 1D cell migration (Invited)
Katrina Adlerz, Helim Aranda-Espinoza |
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| 14:20 pm | Computational study of cell migration behaviors
Xiaowei Zeng, Liqiang Lin |
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Tuesday | T3 15:00pm-16:40pm
| C12-3: Mechanical Behaviors of Cytoskeleton and Cells | ||
| Room 2111 | Session Chair: Taeyoon Kim, Zhangli Peng | Track C: Mechanics of Biological and Soft Materials |
| 15:00 pm | Stress fiber contractile behaviors in aortic valve interstitial cells (Invited)
Michael Sacks, Yusuke Sakamoto, Rachel M. Buchanan, Johannah S. Adams, Farshid Guilak |
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| 15:40 pm | Electrohydrodynamic instability of a lipid bilayer membrane coupled to a cytoskeleton network (Invited)
Yuan-Nan Young |
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| 16:00 pm | Water dynamics and actomyosin mechanics govern cell mechanical behavior (Invited)
Sean Sun |
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| 16:20 pm | Mechanics of red blood cells in human spleen and some consequences for health and disease
Zhangli Peng, Igor Pivkin, George Karniadakis, Pierre Buffet, Ming Dao |
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Wednesday | W1 10:00am-11:40am
| C12-4: Mechanical Behaviors of Cytoskeleton and Cells | ||
| Room 2111 | Session Chair: Taeyoon Kim, Zhangli Peng | Track C: Mechanics of Biological and Soft Materials |
| 10:00 am | How actin polymerization generates pulling forces to bend the cell membrane (Invited)
Anders Einar Carlsson, Dennis Tweten, Philip Bayly |
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| 10:40 am | Mechanochemical modeling of the eukaryotic cytoskeleton (Invited)
Garegin A. Papoian |
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| 11:00 am | 3D model of cytokinetic contractile ring assembly: node-mediated and “backup” pathways (Invited)
Dimitrios Vavylonis, Tamara Bidone |
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| 11:20 am | Morphological transformation, contraction, and force generation of active cytoskeletal structures
Taeyoon Kim, Wonyeong Jung, Jing Li |
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