(Mechanics of Biological and Soft Materials)
Symposium Organizers:
George Lykotrafitis, University of Connecticut
gelyko@engr.uconn.edu
Ying Li, University of Connecticut
yingli@engr.uconn.edu
Symposium Technical Description
Mechanics plays a very significant role in biological systems. For instance, cells actively sense their environment and respond to or send physical signals. Applied forces, geometry, elasticity, and chemistry of the extracellular matrix are important in several biological processes and pathologies. However, the structural complexity of biological systems sets up a major hurdle for the understanding of their behavior. Moreover, multiple spatial and temporal scales are typically involved due to the hierarchical structure and nested process in biological system. All these issues bring unprecedented challenges and also great opportunities to experimental, theoretical and computational molecular, cellular, and tissue mechanics. These challenges call for close collaborations between scientist from different fields including engineers, physicists, biologists, chemists, and material scientists.
The overarching goal of this symposium is to bring together researchers with a variety of backgrounds to exchange ideas, to team up for addressing grand challenge problems, or to initiate new areas of research. We propose three major themes under this symposium:
Tissue Mechanics: Constitutive modeling of biological tissues, experimental measurement of tissue properties, tissue remodeling, structure-function relations of tissue, numerical simulations in tissue mechanics, biological and disease applications of tissue mechanics, biomechanics of cartilage and arteries.
Cellular and subcellular Mechanics: Cell adhesion, cell motility, mechanical properties of single cells, constitutive and computational modeling of cells, single-cell mechanical testing, cell membrane mechanics, cell cytoskeleton and cell-extracellular matrix interactions, mechanotransduction in cells, morphogenesis, intracellular mechanics, multi-cellular structure formation and organization, cellular uptake of nanoparticles.
Molecular Mechanics: Deformation of DNA, RNA and proteins, analytic and computational analysis of biomolecules, mechanisms of mechanosensing and mechanotransduction, cell adhesion molecules, mechanics of subcellular structures and organelles, mechanics of endocytosis, viral budding, viral packaging, self-assembly of nanoparticles mediated by organic molecules.
Technical Program
Tuesday | T1 10:00am-11:40am
| C4-1: Molecular, Cellular, and Tissue Mechanics | ||
| Room 1307 | Session Chair: George Lykotrafitis, Ying Li | Track C: Mechanics of Biological and Soft Materials |
| 10:00 am | Mechanical tension a universal mechanism for matrix remodeling by cells (Invited)
M. Taher A. Saif, Kyung Hwa Choi, Onur Aydin |
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| 10:40 am | Microcavitation as a neuronal damage mechanism in an in vitro model of blast traumatic brain injury
Jonathan B. Estrada, Mark Scimone, Harry Cramer, Paul Hopkins, Christian Franck, Carlos Barajas, Eric Johnsen |
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| 11:00 am | Caveolae mediated SK channel endocytosis in neurons
Krithika Abiraman, Anastasios Tzingounis, George Lykotrafitis |
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| 11:20 am | Bovine cartilage undergoing large-strain shear: anisotropy, heterogeneity and dependence on thickness
Stephany Santos, Franz Maier, David M. Pierce |
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Tuesday | T2 13:00pm-14:40pm
| C4-2: Molecular, Cellular, and Tissue Mechanics | ||
| Room 1307 |
Session Chair: George Lykotrafitis, Ying Li | Track C: Mechanics of Biological and Soft Materials |
| 13:00 pm | Cell and nanoparticle adhesion: multiscale characterization and modeling
Yaling Liu, Salman Sohrabi |
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| 13:20 pm | Modeling cell mechanics using coarse-grained approach
Igor Pivkin, Kirill Lykov |
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| 13:40 pm | Vesiculation and band-3 protein diffusion in the healthy and defective red blood cell membrane
George Lykotrafitis |
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| 14:00 pm | Lipid dipole potential modulates transmembrane movement of a voltage sensor
Mehdi Torbati, Ashutosh Agrawal |
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Tuesday | T3 15:00pm-16:40pm
| C4-3: Molecular, Cellular, and Tissue Mechanics | ||
| Room 1307 |
Session Chair: George Lykotrafitis, Ying Li | Track C: Mechanics of Biological and Soft Materials |
| 15:00 pm | Self-assembly of core-polyethylene glycol-lipid shell (CPLS) nanoparticles and the potential as drug delivery vehicles
Ying Li |
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| 15:20 pm | Stable adhesion of rolling cells to soft substrates
Alireza Sarvestani, Mohammad Moshaei |
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| 15:40 pm | Network mechanics in biological materials: bond dissociations and network measures of damage
Amy Dagro, K.T. Ramesh |
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| 16:00 pm | Complementary curvatures from proteins and lipids catalyze mitochondrial fission via geometric instability
Ashutosh Agrawal |
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| 16:20 pm | Nanorod-mediated mechanical destruction of cell membranes
Liuyang Zhang, Xianqiao Wang |
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