Symposium C-4: Molecular, Cellular, and Tissue Mechanics

(Mechanics of Biological and Soft Materials)

Symposium Organizers:

George Lykotrafitis, University of Connecticut

Ying Li, University of Connecticut

Symposium Technical Description

Mechanics plays a very significant role in biological systems. For instance, cells actively sense their environment and respond to or send physical signals. Applied forces, geometry, elasticity, and chemistry of the extracellular matrix are important in several biological processes and pathologies. However, the structural complexity of biological systems sets up a major hurdle for the understanding of their behavior. Moreover, multiple spatial and temporal scales are typically involved due to the hierarchical structure and nested process in biological system. All these issues bring unprecedented challenges and also great opportunities to experimental, theoretical and computational molecular, cellular, and tissue mechanics. These challenges call for close collaborations between scientist from different fields including engineers, physicists, biologists, chemists, and material scientists.

The overarching goal of this symposium is to bring together researchers with a variety of backgrounds to exchange ideas, to team up for addressing grand challenge problems, or to initiate new areas of research. We propose three major themes under this symposium:

Tissue Mechanics: Constitutive modeling of biological tissues, experimental measurement of tissue properties, tissue remodeling, structure-function relations of tissue, numerical simulations in tissue mechanics, biological and disease applications of tissue mechanics, biomechanics of cartilage and arteries.

Cellular and subcellular Mechanics: Cell adhesion, cell motility, mechanical properties of single cells, constitutive and computational modeling of cells, single-cell mechanical testing, cell membrane mechanics, cell cytoskeleton and cell-extracellular matrix interactions, mechanotransduction in cells, morphogenesis, intracellular mechanics, multi-cellular structure formation and organization, cellular uptake of nanoparticles.

Molecular Mechanics: Deformation of DNA, RNA and proteins, analytic and computational analysis of biomolecules, mechanisms of mechanosensing and mechanotransduction, cell adhesion molecules, mechanics of subcellular structures and organelles, mechanics of endocytosis, viral budding, viral packaging, self-assembly of nanoparticles mediated by organic molecules.

Technical Program 

Tuesday | T1 10:00am-11:40am

C4-1: Molecular, Cellular, and Tissue Mechanics
Room 1307 Session Chair: George Lykotrafitis, Ying Li Track C: Mechanics of Biological and Soft Materials
10:00 am Mechanical tension a universal mechanism for matrix remodeling by cells (Invited)

M. Taher A. Saif, Kyung Hwa Choi, Onur Aydin

10:40 am Microcavitation as a neuronal damage mechanism in an in vitro model of blast traumatic brain injury

Jonathan B. Estrada, Mark Scimone, Harry Cramer, Paul Hopkins, Christian Franck, Carlos Barajas, Eric Johnsen

11:00 am Caveolae mediated SK channel endocytosis in neurons

Krithika Abiraman, Anastasios Tzingounis, George Lykotrafitis

11:20 am Bovine cartilage undergoing large-strain shear: anisotropy, heterogeneity and dependence on thickness

Stephany Santos, Franz Maier, David M. Pierce

Tuesday | T2 13:00pm-14:40pm

C4-2: Molecular, Cellular, and Tissue Mechanics
Room 1307
Session Chair: George Lykotrafitis, Ying Li Track C: Mechanics of Biological and Soft Materials
13:00 pm Cell and nanoparticle adhesion: multiscale characterization and modeling

Yaling Liu, Salman Sohrabi

13:20 pm Modeling cell mechanics using coarse-grained approach

Igor Pivkin, Kirill Lykov

13:40 pm Vesiculation and band-3 protein diffusion in the healthy and defective red blood cell membrane

George Lykotrafitis

14:00 pm Lipid dipole potential modulates transmembrane movement of a voltage sensor

Mehdi Torbati, Ashutosh Agrawal

 Tuesday | T3 15:00pm-16:40pm

C4-3:  Molecular, Cellular, and Tissue Mechanics
Room 1307
Session Chair: George Lykotrafitis, Ying Li Track C: Mechanics of Biological and Soft Materials
15:00 pm Self-assembly of core-polyethylene glycol-lipid shell (CPLS) nanoparticles and the potential as drug delivery vehicles

Ying Li

15:20 pm Stable adhesion of rolling cells to soft substrates

Alireza Sarvestani, Mohammad Moshaei

15:40 pm Network mechanics in biological materials: bond dissociations and network measures of damage

Amy Dagro, K.T. Ramesh

16:00 pm Complementary curvatures from proteins and lipids catalyze mitochondrial fission via geometric instability

Ashutosh Agrawal

16:20 pm Nanorod-mediated mechanical destruction of cell membranes

Liuyang Zhang, Xianqiao Wang